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KMID : 1134820070360101271
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Journal of the Korean Society of Food Science and Nutrition
2007 Volume.36 No. 10 p.1271 ~ p.1278
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Ethanol Induced Leucocytic and Hepatic DNA Strand Breaks Are Prevented by Styela clava and Styela plicata Supplementation in Male SD Rats
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Kim Jung-Mi
Park Hae-Ryong
Park Eun-Ju
Lee Seung-Cheol
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Abstract
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In this study, the ability of Styela clava or Styela plicata to reduce ethanol-induced hepatotoxicity and hepatic and leucocytic DNA damages was evaluated. Twenty four male SD rats were given 25% ethanol containing water (ad lib, p.o.) and divided into 3 groups; ethanol treated control group (EtOH), ethanol＋3% S. clava (EtOH＋SC), and ethanol＋3% S. plicata (EtOH＋SP). After 6 weeks, the supplementation of S. clava reduced the plasma ALT, ALP and LDH activities significantly (p＜0.05), while S. plicata induced significant decrease in the plasma LDH activity only. The comet assay was employed to quantify the alcohol-induced DNA damage in rat hepatocytes and leucocytes. A significant protective effect on hepatic and leucocytic DNA damages was observed in S. clava or S. plicata supplemented groups compared to the EtOH control group. The hepatic DNA damage was correlated positively with plasma ALP and LDH activities. These results demonstrated that S. clava or S. plicata supplementation protected alcohol-induced hepatic and leucocytic DNA damage.
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KEYWORD
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Styela clava, Styela plicata, alcohol, liver function, DNA damage
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